INDIANAPOLIS — Broncos backup quarterback Brock Osweiler made the most of his chance Thursday, throwing for two touchdowns and running for another to lead Denver to a 25-13 NFL victory over the Colts.

Osweiler came into the game after starter Trevor Siemian left with left shoulder injury after he was sacked in the first quarter and completed 12 of 17 passes for 194 yards.

It was a fifth straight defeat for the Colts, who fell to 3-11 and saw several players injured.

Colts tight end Brandon Williams was carted off the field after a scary incident in which he was hurt while blocking on an Indianapolis punt in the first minute of the second quarter.

After crumpling to the field, Williams was tended by medical personnel who strapped him to a back board before he was carted off.

Williams, who suffered a concussion, was “doing well” after he was treated and released from hospital, the Colts said.

In the third quarter the Colts lost Jeremiah George to a neck injury along with fellow linebacker Jon Bostic and right guard Denzelle Good, both with knee injuries.

The Colts were up 10-7 at halftime and increased their lead to 13-7 on a 39-yard field goal by Adam Vinatieri.

But the Broncos scored the final 18 points.

Denver took the lead on Osweiler’s 22-yard touchdown pass to Cody Latimer with 4:16 to play in the third quarter.

Osweiler’s 54-yard TD pass to Jeff Heuerman, followed by a two-point conversion pass to Latimer, pushed Denver’s lead to 22-13.

Denver boosted the lead to 25-13 on a 40-yard field goal by Brandon McManus with 5:13 remaining.

Colts quarterback Jacoby Brissett completed 17 of 30 passes for 158 yards.

Kenny Moore II made his first career interception on the Broncos’ first possession, picking off Siemian and returning it 25 yards to the 50. Brissett then scampered seven yards for a touchdown that put the Colts up 7-0.

The Broncos responded with a drive to the Colts’ seven-yard-line. But after two incomplete passes Siemian was injured and McManus missed a 40-yard field-goal attempt.

After a Colts field goal, Osweiler marched the Broncos 75 yards on 11 plays, capping the drive with a an 18-yard touchdown run after having an apparent touchdown pass nullified by a penalty. — AFP