ANAHEIM — The Red Sox and a blister teamed up to knock out Los Angeles Angels sensation Shohei Ohtani, and Boston posted a 10-1 win in a game matching the teams with the two best records in the majors Tuesday night at Anaheim.

With Mookie Betts’ three home runs leading the way, the Red Sox ended the Angels’ winning streak at seven games while extending their own winning streak to five. Jackie Bradley Jr., Brock Holt and Rafael Devers also went deep for Boston.

Ohtani left after two innings, and the Angels announced that his exit was caused by a blister on his right (pitching) hand. However, the Red Sox had already roughed up the Japanese star for three runs and four hits in the opening two frames.

It was clear right from the start that Ohtani’s fate would be quite different than his previous start on April 8, when he didn’t allow an Oakland A’s batter to reach base until the seventh inning. Betts led off the game with the first of his three homers. The Boston right fielder also homered in the third and eighth innings.

Diamondbacks 1, Giants 0

David Peralta singled in a run to break up a scoreless tie in the eighth inning, and Patrick Corbin pitched a one-hitter in Arizona’s victory over visiting San Francisco.

Jarrod Dyson walked with one out in the eighth inning off Tony Watson (1-1) and took second on Corbin’s sacrifice bunt. Peralta then singled up the middle as the D-backs (12-4) tied the best start in franchise history.

Corbin (3-0) gave up a walk and a two-out, eighth-inning single while pitching his first career complete game. He struck out eight, relying mainly on a slider. He is tied for the NL lead in victories.

Marlins 9, Yankees 1: Jarlin Garcia escaped trouble in five scoreless innings for his first win as a starting pitcher, and J.T. Realmuto hit a three-run homer in his season debut as Miami beat host New York as a restless home crowd continued to lustily boo former Marlins star and current Yankee Giancarlo Stanton.

Astros 4, Mariners 1: Lance McCullers Jr. allowed just one hit in seven innings and struck out 11 batters as Houston defeated host Seattle thanks to Brian McCann’s tiebreaking two-run homer in the sixth inning.

Indians 6, Twins 1: Francisco Lindor, Jose Ramirez, Michael Brantley and Yonder Alonso hit home runs to back the strong pitching of Corey Kluber (2-1), lifting Cleveland over Minnesota, which was serving as host in the opener of a two-game series in San Juan, Puerto Rico.

A’s 10, White Sox 2: Jed Lowrie ignited a five-run first inning with a home run, and Trevor Cahill threw seven innings of shutout ball as Oakland celebrated “Free Baseball” on their 50th anniversary with a 10-2 trouncing of visiting Chicago.

Dodgers 7, Padres 3 (12 innings): Yasmani Grandal and Kyle Farmer hit two-run doubles in the top of the 12th inning to give Los Angeles a win at San Diego.

Cardinals 5, Cubs 3: Matt Carpenter knocked in three runs, and Paul DeJong homered as visiting St. Louis stretched its winning streak to five games by dropping Chicago.

Rockies 2, Pirates 0: Colorado starter Chad Bettis combined with three relievers for a five-hit shutout against host Pittsburgh. The Rockies didn’t muster a great deal of offense — just five hits, same as the Pirates — but a run each in the first and fourth innings sufficed.

Nationals 5, Mets 2: Trea Turner had three hits and two runs, and visiting Washington never trailed in a win over New York, aided by Wilmer Difo and Pedro Severino hitting back-to-back RBI singles in the fourth.

Phillies 5, Braves 1 (10 innings): Rhys Hoskins drove in two runs with a two-out double to spark a four-run rally in the 10th inning, helping Philadelphia outlast host Atlanta.

Tigers 4, Orioles 2: Victor Martinez clubbed his first homer of the season, and host Detroit snapped its five-game losing streak by edging Baltimore as starter Francisco Liriano and four relievers recorded a combined 12 strikeouts.

Brewers 2, Reds 0: Milwaukee first baseman Eric Thames, who torched Cincinnati pitching for 10 of his 31 home runs last season, launched a two-run shot to right field off Reds right-hander Sal Romano in the sixth inning to send the home crowd home happy.

Blue Jays 11, Royals 3 (Game 1): Yangervis Solarte hit a home run and had four RBIs, Randal Grichuk added a three-run homer and host Toronto blasted visiting Kansas City in the first game of a doubleheader.

Blue Jays 5, Royals 4 (10 innings, Game 2):

Luke Maile drove in the winning run with a single in the 10th inning and had three RBIs in the game as Toronto swept Kansas City in a doubleheader.

Rangers 7, Rays 2: Shin-Soo Choo hit a solo home run and scored four times to back seven strong innings from Matt Moore as Texas rolled over host Tampa Bay. — Reuters