WASHINGTON — A two-dose version of Johnson & Johnson's coronavirus vaccine provides 94% protection against symptomatic infection, the company said Tuesday — making a two-dose regimen of J&J's Janssen vaccine comparable to a two-dose regimen of Moderna's or Pfizer's.

Plus, the company said, adding a booster dose to a single shot of the vaccine raised immunity even more, and should also protect people strongly against infection.

The company released some details of three studies looking at various aspects of its Janssen vaccine, and said that, taken together, they showed the vaccine provided long-lasting protection that could be boosted with an extra shot.

"Our large real-world-evidence and Phase 3 studies confirm that the single-shot Johnson & Johnson vaccine provides strong and long-lasting protection against COVID-19-related hospitalizations," Dr. Mathai Mammen, global head of Janssen Research & Development, said in a statement.

"Our single-shot vaccine generates strong immune responses and long-lasting immune memory. And, when a booster of the Johnson & Johnson COVID-19 vaccine is given, the strength of protection against COVID-19 further increases."

Johnson & Johnson's single-dose vaccine was given emergency use authorization by the US Food and Drug Administration on Feb. 27. It has been given to about 14.8 million Americans, according to the US Centers for Disease Control and Prevention.

The company's ongoing Phase 2 trial of a two-dose regimen showed giving two doses 56 days apart provided 100% protection against severe Covid-19 and 94% protection against moderate to severe COVID-19 in the United States. Globally, the two-dose regimen provided 75% protection against moderate-to-severe COVID-19, the company said.

A second study showed people given a booster shot six months or longer after their first dose had a 12-fold increase in antibodies — compared to a four-fold increase for people who got a second dose at two months. So protection should be stronger if people get boosters later, Dr. Dan Barouch, head of Beth Israel Deaconess' Center for Virology and Vaccine Research, told CNN.

"If you wait longer and have boost at six months or later then you likely will have better boost," said Barouch.

Third, the company said a real-world evidence study of 390,000 people in the US, using health insurance records through July -- so covering the Delta variant — showed the one-shot J&J vaccine was 81% effective at preventing hospitalizations.

"The Johnson & Johnson single-shot COVID-19 vaccine showed vaccine effectiveness against COVID-19-related hospitalizations at 86% for participants younger than 60 years, and 78% for those 60 years and older," the company said.

"Among 390,517 vaccinated and 1,524,153 matched unvaccinated individuals, vaccine effectiveness 79% for COVID-19 and 81% for COVID-19-related hospitalizations," the Janssen-led research team wrote in a study posted online in a preprint.

"In high-Delta-incidence states, rates of observed COVID-19 were higher in both groups than in the national cohort," they added. "In these states, vaccine effectiveness for observed COVID-19 was 79% overall and 78% during June and July, the months where Delta variant incidence was highest," they added.

Barouch, who has worked with Janssen to test the vaccine but who was not directly involved in the three studies, said people who got the Johnson & Johnson vaccine should be reassured by the data.

"All the vaccines in the US have shown robust and durable protection against severe disease and hospitalization," he said. "Ultimately, the job of a vaccine is to keep you from being sick and keep you from going into the hospital and to keep you alive, and all of the vaccines are doing that."

Data on the J&J vaccine has come later than data about the Moderna and Pfizer/BioNTech vaccines because J&J's was authorized around two months later. Johnson & Johnson has said it will submit all of this data to the FDA for potential consideration for adding a booster dose, and perhaps for consideration to authorize a two-dose regimen.

The Janssen vaccine is made using a different technology from Moderna's and Pfizer's vaccines. They deliver messenger RNA or mRNA directly to the body wrapped in compounds called lipids. The J&J vaccine is made using an adenovirus, a common cold virus, that's been engineered so it can get into cells, but then stops. It delivers genetic instructions that way.

Barouch said there is room for a variety of approaches. "A single shot gives robust and durable protection over a substantial period of time of time with minimal evidence of decline," Barouch said.

"I think the single dose vaccine is a reasonable option for people and for countries that want a simple and convenient vaccine that can be administered quickly," he added.

"For outstanding protection, then a second shot can be given at any time between two months and eight months — and the longer you wait, the better."

Barouch said the J&J vaccine may appear less effective in countries outside the United States because it was tested in many countries when variants were circulating that can evade the protection offered by vaccines. — CNN