JERUSALEM — Palestinians and Israeli forces have clashed in and around the Al-Aqsa Mosque in Jerusalem's Old City, marking a significant spike in tensions on what is a day of significance for all three Abrahamic religions.

Videos shared on social media showed serious unrest and violence at the entrance to the mosque building from before sunrise with Palestinians throwing stones and firecrackers and Israeli security forces firing what appeared to be stun grenades and tear gas.

There were also early clashes at the Lions' Gate entrance to the Old City.

By mid-morning, the Palestinian Red Crescent said more than 150 people had been taken to hospital with injuries from rubber bullets and stun grenades, as well as wounds sustained from beatings by police.

Among those injured was a cameraman, Rami Khatib, who suffered a broken hand. Video shows him being kicked and beaten by police officers.

Earlier, police released CCTV video showing masked men apparently preparing for clashes overnight by smashing up rocks and gathering them in black buckets.

Police said several officers were taken to hospitals after they were hit by rocks.

Following initial clashes on the compound and at the doors to the mosque, Israeli police entered the building around 9:30 a.m., as evidenced by numerous social media videos.

Worshippers could be seen lying on the ground apparently detained, as dozens of police stood over them.

Other videos show heavy smoke inside the mosque and the constant sound of firecrackers and stun grenades going off.

The presence of Israeli police inside the Al-Aqsa mosque compound is inherently sensitive to many Muslims and Palestinians. It is also regarded as putting a strain on a "status quo" agreement between Israel and Jordan governing arrangements at the religious site.

Israeli police said they made more than 300 arrests inside the mosque but insisted they had only entered the compound because those throwing rocks were jeopardizing safe worship.

At the Damascus Gate entrance to the Old City, one of the main entrances for Muslims on their way to the Al-Aqsa mosque, police briefly prevented people from entering.

Earlier, at entrances to the mosque compound, police were allowing older men and women to enter, but preventing young men from joining them.

In a statement, Israeli police said violence broke out at 4 a.m. local time Friday (9 p.m. ET Thursday) when "dozens of young Palestinian lawbreakers, some of them with heads covered, began to march around Temple Mount, with Hamas and Palestinian Authority flags, letting off fireworks and throwing stones."

Israel's Foreign Minister, Yair Lapid, paid tribute to security forces, saying they had acted with sensitivity and determination, adding, "The riots this morning on the Temple Mount are unacceptable and go against the spirit of the religions we believe in."

But the disturbances also prompted sharp criticism of Israeli forces' actions, in particular the decision to enter the mosque building wearing shoes, which is seen by Muslims as deeply disrespectful.

Saudi Arabia expressed condemnation and denunciation of the Israeli occupation forces' storming of Al-Aqsa Mosque, closing its gates and attacking defenseless worshipers inside it and inside its external squares.

"This systematic escalation is a blatant attack on the sanctity of Al-Aqsa Mosque and its status in the conscience of the Islamic nation, and a violation of relevant international resolutions and charters."

The Kingdom also called on the international community to play its role in holding the Israeli occupation forces fully responsible for the repercussions of the continuation of such crimes and violations on the defenseless Palestinian people, their territory and their holy sites, as well as on the chances of reviving the peace process in the Middle East.

Jordan, which has a special role as custodian of the Al-Aqsa Mosque, has condemned what it described as the storming of the compound, calling it a "flagrant violation."

A spokesperson for the Palestinian Authority Presidency called it a "dangerous development."

In Jeddah, the Secretariat General of the Organization of Islamic Cooperation (OIC) strongly denounced Israeli forces for entering Al-Aqsa Mosque and closing its gates to worshippers.

The OIC considered this dangerous escalation as an attack against the feelings of the entire Islamic nation and a flagrant violation of the international resolutions and charters.

In a statement, OIC held the Israeli occupation responsible for the repercussions of daily crimes and offenses against the Palestinian people, their territories and sanctuaries.

OIC also called on the UN Security Council to shoulder its responsibility to protect the Palestinian people as well as the sacred places and prevent the repetition of the Israeli attacks fueling extremism, religious conflict and instability in the region.

The United Arab List, one of the eight parties in Israel's governing coalition, spoke of the sanctity of the mosque being violated.

While tensions have been very high in Israel and the West Bank in recent weeks, following a series of violent attacks and incidents, Jerusalem itself has been calm.

But fears of possible clashes in the city have been growing following comments by both Jewish extremists and Palestinian militant groups.

Hamas has accused Israel of a series of provocations in Jerusalem, most recently calling on Palestinians to defend the mosque "with all possible means" after an extremist Jewish group called for an animal sacrifice on the Temple Mount to mark the start of Passover, which begins Friday.

The Rabbi of the Western Wall Friday morning called on Muslim leaders to act to stop the violence, as well as repeating his opposition to the raising of an animal sacrifice to the Temple Mount.

While Muslims are marking the second Friday of the holy month of Ramadan, and Jews are preparing for the start of the Passover holiday, Christians from Western churches are marking Good Friday. From early morning, small groups could be seen making their way through the Old City towards the Church of the Holy Sepulchre, which Christians believe stands on the site where Jesus was crucified.

But Friday morning's scenes have brought back memories of one year ago, when violence in Jerusalem was seized on by Hamas who fired rockets at the city, triggering an 11-day war between militants in Gaza and the Israeli army. — Agencies